Park7<tm1Xz> Targeted Allele Detail MGI Mouse (MGI:3586448)

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Park7^tm1Xz
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Summary

Symbol:	Park7^tm1Xz
Name:	Parkinson disease (autosomal recessive, early onset) 7; targeted mutation 1, Xiaoxi Zhuang
MGI ID:	MGI:3586448
Synonyms:	DJ-1^-
Gene:	Park7 Location: Chr4:150981590-150994378 bp, - strand Genetic Position: Chr4, 81.52 cM, cytoband E1
Alliance:	Park7^tm1Xz page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:99905
Parent Cell Line:	E14TG2a.4 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A PGK-neo cassette flanked by FRT sites replaced the first five exons and part of the promoter. RT-PCR confirmed absence of transcript in mutant skin fibroblasts. (J:99905)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Park7 Mutation:	56 strains or lines available

References

Original:	J:99905 Chen L, et al., Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice. J Biol Chem. 2005 Jun 3;280(22):21418-26
All:	12 reference(s)

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