Cks2<tm1Sir> Targeted Allele Detail MGI Mouse (MGI:3586897)

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Cks2^tm1Sir
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Cks2^tm1Sir
Name:	CDC28 protein kinase regulatory subunit 2; targeted mutation 1, Steven I Reed
MGI ID:	MGI:3586897
Synonyms:	CKS2^-
Gene:	Cks2 Location: Chr13:51799268-51804696 bp, + strand Genetic Position: Chr13, 26.12 cM
Alliance:	Cks2^tm1Sir page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:99997
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: A targeting construct was designed to insert a PGK-neo into exon 1, thereby eliminating 92% of the coding sequence. Western blot confirmed absence of protein in mutant MEFs. (J:99997)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Cks2 Mutation:	33 strains or lines available

References

Original:	J:99997 Spruck CH, et al., Requirement of Cks2 for the first metaphase/anaphase transition of mammalian meiosis. Science. 2003 Apr 25;300(5619):647-50
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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