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Atg7tm1.1Tchi
Targeted Allele Detail
Summary
Symbol: Atg7tm1.1Tchi
Name: autophagy related 7; targeted mutation 1.1, Tomoki Chiba
MGI ID: MGI:3587771
Synonyms: Atg7-
Gene: Atg7  Location: Chr6:114620075-114837565 bp, + strand  Genetic Position: Chr6, 53.05 cM, cytoband E3
Alliance: Atg7tm1.1Tchi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:100199
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation details: Crossing Atg7tm1Tchi with mice expressing cre recombinase in oocytes resulted in the loss of exon 14. Neither transcript nor protein was detected in mutants. Loss of activity was also detected in neonate livers by examining the ATG conjugation systems. (J:100199)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Atg7 Mutation:  51 strains or lines available
References
Original:  J:100199 Komatsu M, et al., Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol. 2005 May 9;169(3):425-34
All:  37 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory