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Gdf7tm3(cre)Tmj
Targeted Allele Detail
Summary
Symbol: Gdf7tm3(cre)Tmj
Name: growth differentiation factor 7; targeted mutation 3, Thomas M Jessell
MGI ID: MGI:3588567
Synonyms: Gdf7-cre, Gdf7cre
Gene: Gdf7  Location: Chr12:8347918-8351954 bp, - strand  Genetic Position: Chr12, 3.85 cM
Alliance: Gdf7tm3(cre)Tmj page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60594
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Gdf7tm3(cre)Tmj expression driven by 1 gene
 
Mutation details: Cre recombinase cDNA and an FRT-flanked neo was inserted downstream of the coding sequence such that expression of cre would be directed by Gdf7 regulatory elements. Expression was shown to recapitulate roof-plate-specific expression of Gdf7. (J:60594)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Gdf7 (mouse)
Summary of all recombinase alleles driven by Gdf7.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gdf7 Mutation:  16 strains or lines available
References
Original:  J:60594 Lee KJ, et al., Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification [see comments]. Nature. 2000 Feb 17;403(6771):734-40
All:  6 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory