Chd7<Whi> Chemically induced Allele Detail MGI Mouse (MGI:3588650)

Chd7^Whi
Chemically induced Allele Detail

Summary

Symbol:	Chd7^Whi
Name:	chromodomain helicase DNA binding protein 7; whirligig
MGI ID:	MGI:3588650
Synonyms:	WBE1
Gene:	Chd7 Location: Chr4:8690406-8867659 bp, + strand Genetic Position: Chr4, 3.68 cM
Alliance:	Chd7^Whi page

Malformations of the semicircular canals in Chd7^Whi/Chd7⁺, Tbx1^tm1Bld/Tbx1⁺, and Chd7^Whi/Chd7⁺ Tbx1^tm1Bld/Tbx1⁺ mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin

Strain of Origin:

C3HeB/FeJ

Mutation
description

Allele Type:		Chemically induced (ENU)
Mutation:		Single point mutation
		Mutation details: A G2918A transition in exon 11 resulted in a W973X nonsense mutation. This mutation would lead to a protein lacking a large part of the SNF2 and all other more C-terminal located domains. (J:104123)
Inheritance:		Dominant

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	9 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	26 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Chd7 Mutation:	138 strains or lines available

References

Original:	J:99481 Hawker K, et al., Two new mouse mutants with vestibular defects that map to the highly mutable locus on chromosome 4. Int J Audiol. 2005 Mar;44(3):171-7
All:	9 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24