Chd7<Whi> Chemically induced Allele Detail MGI Mouse (MGI:3588650)

Chd7^Whi
Chemically induced Allele Detail

Summary

Symbol:	Chd7^Whi
Name:	chromodomain helicase DNA binding protein 7; whirligig
MGI ID:	MGI:3588650
Synonyms:	WBE1
Gene:	Chd7 Location: Chr4:8690406-8867659 bp, + strand Genetic Position: Chr4, 3.68 cM
Alliance:	Chd7^Whi page

Malformations of the semicircular canals in Chd7^Whi/Chd7⁺, Tbx1^tm1Bld/Tbx1⁺, and Chd7^Whi/Chd7⁺ Tbx1^tm1Bld/Tbx1⁺ mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin

Strain of Origin:

C3HeB/FeJ

Mutation
description

Allele Type:		Chemically induced (ENU)
Mutation:		Single point mutation
		Mutation details: A G2918A transition in exon 11 resulted in a W973X nonsense mutation. This mutation would lead to a protein lacking a large part of the SNF2 and all other more C-terminal located domains. (J:104123)
Inheritance:		Dominant

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	9 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	26 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Chd7 Mutation:	138 strains or lines available

References

Original:	J:99481 Hawker K, et al., Two new mouse mutants with vestibular defects that map to the highly mutable locus on chromosome 4. Int J Audiol. 2005 Mar;44(3):171-7
All:	9 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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