Bax<tm2Sjk> Targeted Allele Detail MGI Mouse (MGI:3589203)

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Bax^tm2Sjk
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Bax^tm2Sjk
Name:	BCL2-associated X protein; targeted mutation 2, Stanley J Korsmeyer
MGI ID:	MGI:3589203
Synonyms:	Bax^fl
Gene:	Bax Location: Chr7:45111121-45116322 bp, - strand Genetic Position: Chr7, 29.32 cM, cytoband B5
Alliance:	Bax^tm2Sjk page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:100463
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: LoxP sites were inserted to flank exons 2-4. A loxP-flanked neo was removed via cre-mediated recombination. (J:100463)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Bax Mutation:	24 strains or lines available

References

Original:	J:100463 Takeuchi O, et al., Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11272-7
All:	96 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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