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Bcl2l11tm1Sjk
Targeted Allele Detail
Summary
Symbol: Bcl2l11tm1Sjk
Name: BCL2 like 11; targeted mutation 1, Stanley J Korsmeyer
MGI ID: MGI:3589204
Synonyms: Bim-
Gene: Bcl2l11  Location: Chr2:127967958-128004467 bp, + strand  Genetic Position: Chr2, 62.23 cM, cytoband F3-G1
Alliance: Bcl2l11tm1Sjk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:100463
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation details: The first four exons were deleted via homologous recombination. Lack of aberrant protein was confirmed in mutant ES cells. This allele was generate from Bcl2l11tm2Sjk. (J:100463)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bcl2l11 Mutation:  36 strains or lines available
References
Original:  J:100463 Takeuchi O, et al., Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11272-7
All:  10 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory