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Gpx1tm1Mgr
Targeted Allele Detail
Summary
Symbol: Gpx1tm1Mgr
Name: glutathione peroxidase 1; targeted mutation 1, Grant R MacGregor
MGI ID: MGI:3589261
Synonyms: Gpx1-
Gene: Gpx1  Location: Chr9:108216279-108217541 bp, + strand  Genetic Position: Chr9, 59.24 cM, cytoband F1
Alliance: Gpx1tm1Mgr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:62395
Parent Cell Line:  AK7.1 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: The two exons were replaced with a PGK-neo cassette. Western blot of mutant brain tissue lysate failed to detect protein. (J:62395)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gpx1 Mutation:  21 strains or lines available
References
Original:  J:62395 Esposito LA, et al., Mitochondrial oxidative stress in mice lacking the glutathione peroxidase-1 gene. Free Radic Biol Med. 2000 Mar 1;28(5):754-66
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory