Ndel1<tm2Shr> Targeted Allele Detail MGI Mouse (MGI:3589467)

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Ndel1^tm2Shr
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Ndel1^tm2Shr
Name:	nudE neurodevelopment protein 1 like 1; targeted mutation 2, Shinji Hirotsune
MGI ID:	MGI:3589467
Synonyms:	Ndel1^cko, Ndel1^cko(IV)
Gene:	Ndel1 Location: Chr11:68712260-68743961 bp, - strand Genetic Position: Chr11, 42.09 cM
Alliance:	Ndel1^tm2Shr page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:100552
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Mutation
description

Allele Type:		Targeted (Conditional ready, Hypomorph)
Mutation:		Insertion
		Mutation details: A targeting vector was designed to insert loxP sites to flank exon IV. A floxed neo was included in the vector. This allele acts as a hypomorph with expression suppressed to 30%. (J:100552)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Ndel1 Mutation:	40 strains or lines available

References

Original:	J:100552 Sasaki S, et al., Complete loss of Ndel1 results in neuronal migration defects and early embryonic lethality. Mol Cell Biol. 2005 Sep;25(17):7812-27
All:	5 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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