Htttm3Szi
Targeted Allele Detail
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| Symbol: |
Htttm3Szi |
| Name: |
huntingtin; targeted mutation 3, Scott Zeitlin |
| MGI ID: |
MGI:3603606 |
| Synonyms: |
HdhdeltaQ |
| Gene: |
Htt Location: Chr5:34919084-35069878 bp, + strand Genetic Position: Chr5, 17.92 cM
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| Alliance: |
Htttm3Szi page
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| Allele Type: |
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Targeted (Inserted expressed sequence, Reporter) |
| Mutation: |
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Insertion
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Mutation details: A targeting vector was designed to delete the (CAG)2CAA(CAG)4 triplet repeat encoding 7 glutamines within exon 1. A FLAG epitope tag was included at the N-terminus of the coding sequence in exon 1 to follow expression. A floxed PGK-neo was inserted ~1.3 kb upstream of the transcriptional start site in the opposite transcription orientation.
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Htt Mutation: |
178 strains or lines available
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| Original: |
J:106763 Clabough EB, et al., Deletion of the triplet repeat encoding polyglutamine within the mouse Huntington's disease gene results in subtle behavioral/motor phenotypes in vivo and elevated levels of ATP with cellular senescence in vitro. Hum Mol Genet. 2006 Feb 15;15(4):607-23 |
| All: |
2 reference(s) |
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Analysis Tools
