Itpr2<tm1Kmik> Targeted Allele Detail MGI Mouse (MGI:3604623)

Itpr2^tm1Kmik
Targeted Allele Detail

Summary

Symbol:	Itpr2^tm1Kmik
Name:	inositol 1,4,5-triphosphate receptor 2; targeted mutation 1, Katsuhiko Mikoshiba
MGI ID:	MGI:3604623
Synonyms:	IP3R2^-
Gene:	Itpr2 Location: Chr6:146009797-146403721 bp, - strand Genetic Position: Chr6, 77.7 cM
Alliance:	Itpr2^tm1Kmik page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:101380
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: The first exon coding the first six amino acids was fused in-frame to the lacZ gene with an NLS. Immunoblot failed to detect protein in mutants. (J:101380)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Itpr2 Mutation:	147 strains or lines available

References

Original:	J:101380 Futatsugi A, et al., IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism. Science. 2005 Sep 30;309(5744):2232-4
All:	24 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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