Asl<tm1Wjc> Targeted Allele Detail MGI Mouse (MGI:3604881)

Asl^tm1Wjc
Targeted Allele Detail

Summary

Symbol:	Asl^tm1Wjc
Name:	argininosuccinate lyase; targeted mutation 1, William J Craigen
MGI ID:	MGI:3604881
Synonyms:	AL^-
Gene:	Asl Location: Chr5:130040099-130053222 bp, - strand Genetic Position: Chr5, 68.37 cM
Alliance:	Asl^tm1Wjc page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:101658
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1^b-m2

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Exons 8 and 9 were replaced with a neomycin resistance cassette, creating an out of frame transcript beginning at exon 10. (J:101658)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Asl Mutation:	26 strains or lines available

References

Original:	J:101658 Reid Sutton V, et al., A mouse model of argininosuccinic aciduria: biochemical characterization. Mol Genet Metab. 2003 Jan;78(1):11-6
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24