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Shox2tm1Ypc
Targeted Allele Detail
Summary
Symbol: Shox2tm1Ypc
Name: SHOX homeobox 2; targeted mutation 1, YiPing Chen
MGI ID: MGI:3605739
Synonyms: Shox2-
Gene: Shox2  Location: Chr3:66879060-66889104 bp, - strand  Genetic Position: Chr3, 30.76 cM, cytoband E3-F1
Alliance: Shox2tm1Ypc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101732
Parent Cell Line:  JM-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A PGK-neo cassette replaced exon 3, which encodes the homeodomain. RT-PCR confirmed absence of expression in mutants. (J:101732)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 89 assay results
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Shox2 Mutation:  20 strains or lines available
References
Original:  J:101732 Yu L, et al., Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate. Development. 2005 Oct;132(19):4397-406
All:  7 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory