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Adamts13tm1Dgi
Targeted Allele Detail
Summary
Symbol: Adamts13tm1Dgi
Name: ADAM metallopeptidase with thrombospondin type 1 motif 13; targeted mutation 1, David Ginsburg
MGI ID: MGI:3605825
Synonyms: Adamts13-
Gene: Adamts13  Location: Chr2:26863428-26899640 bp, + strand  Genetic Position: Chr2, 19.14 cM
Alliance: Adamts13tm1Dgi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101752
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced exons 1-6. RT-PCR of mutant liver samples confirmed absence of transcript. (J:101752)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
Allelic CompositionGenetic BackgroundCell Line(s)
 
involves: 129X1/SvJ * C57BL/6J
 
involves: 129X1/SvJ * C57BL/6J * CASA/Rk
 
 
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * CASA/Rk
 
Phenotypes:
Affected Systems
show or hide all annotated terms
         
hematopoietic system
N
hematopoietic system phenotype
N N
abnormal erythrocyte morphology
abnormal platelet morphology
thrombocytopenia
abnormal platelet physiology
homeostasis/metabolism
homeostasis/metabolism phenotype
N N
abnormal platelet physiology
increased circulating von Willebrand factor level
abnormal thrombosis
decreased susceptibility to induced thrombosis
increased susceptibility to induced thrombosis
decreased susceptibility to xenobiotic induced morbidity/mortality
decreased physiological sensitivity to xenobiotic
immune system
immune system phenotype
N
increased susceptibility to bacterial infection
mortality/aging
mortality/aging
N
decreased susceptibility to xenobiotic induced morbidity/mortality
premature death
normal phenotype
no abnormal phenotype detected
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adamts13 Mutation:  70 strains or lines available
References
Original:  J:101752 Motto DG, et al., Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice. J Clin Invest. 2005 Oct;115(10):2752-61
All:  37 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory