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Slc7a11tm1Hsat
Targeted Allele Detail
Summary
Symbol: Slc7a11tm1Hsat
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 11; targeted mutation 1, Hideyo Sato
MGI ID: MGI:3608695
Synonyms: xCT-
Gene: Slc7a11  Location: Chr3:50319385-50403947 bp, - strand  Genetic Position: Chr3, 21.72 cM, cytoband D
Alliance: Slc7a11tm1Hsat page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:102902
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details: GFP and a Neo cassette were introduced into exon 1 via homologous recombination. Crossing with Cre-recombinase-expressing mice removed the neo cassette. Northern blot analysis confirmed absence of mRNA in brain and thymus and peritoneal macrophages. (J:102902)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 43 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc7a11 Mutation:  49 strains or lines available
References
Original:  J:102902 Sato H, et al., Redox imbalance in cystine/glutamate transporter-deficient mice. J Biol Chem. 2005 Nov 11;280(45):37423-9
All:  26 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory