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Gjc1tm2Kni
Targeted Allele Detail
Summary
Symbol: Gjc1tm2Kni
Name: gap junction protein, gamma 1; targeted mutation 2, Kiyomasa Nishii
MGI ID: MGI:3608701
Synonyms: Cx45flox type 1
Gene: Gjc1  Location: Chr11:102690405-102710526 bp, - strand  Genetic Position: Chr11, 66.48 cM
Alliance: Gjc1tm2Kni page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:103078
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: The entire coding exon was flanked with loxP sites followed by an nls-LacZ. The original construct also included a floxed neo cassette. The presence or absence of this cassette does not alter the phenotype. (J:103078, J:231835)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 30 assay results
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gjc1 Mutation:  33 strains or lines available
References
Original:  J:103078 Nishii K, et al., Mice lacking connexin45 conditionally in cardiac myocytes display embryonic lethality similar to that of germline knockout mice without endocardial cushion defect. Cell Commun Adhes. 2003 Jul-Dec;10(4-6):365-9
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory