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Men1tm1Mmey
Targeted Allele Detail
Summary
Symbol: Men1tm1Mmey
Name: multiple endocrine neoplasia 1; targeted mutation 1, Matthew Meyerson
MGI ID: MGI:3608952
Synonyms: Men1-
Gene: Men1  Location: Chr19:6385009-6390921 bp, + strand  Genetic Position: Chr19, 4.45 cM, cytoband A
Alliance: Men1tm1Mmey page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:88588
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation details: A targeting construct was designed to remove exons 3-6 using cre-mediated recombination, leading to a frameshift causing a premature stop codon in exon 7. This allele was generated using Men1tm2.1Mmey. (J:88588)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Men1 Mutation:  40 strains or lines available
References
Original:  J:88588 Hughes CM, et al., Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. Mol Cell. 2004 Mar 27;13(4):587-97
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory