Gnas<tm5.1Lsw> Targeted Allele Detail MGI Mouse (MGI:3609165)

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Gnas^tm5.1Lsw
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Summary

Symbol:	Gnas^tm5.1Lsw
Name:	GNAS complex locus; targeted mutation 5.1, Lee S Weinstein
MGI ID:	MGI:3609165
Synonyms:	E1^fl, Galphas^fl, Gnas^fl, Gnas^lox, Gsalpha^f, Gsalpha^fl
Gene:	Gnas Location: Chr2:174126113-174188537 bp, + strand Genetic Position: Chr2, 97.89 cM, cytoband E1-H3
Alliance:	Gnas^tm5.1Lsw page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:102504
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: A targeting vector was designed to contain a floxed neo at position -1601 (upstream of exon 1) and a third loxP site downstream of exon 1 at position 419. Crossing with mice expressing cre in the germline removed the neo, leaving exon 1 flanked by loxP sites. (J:99237)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	35 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Gnas Mutation:	54 strains or lines available

References

Original:	J:99237 Chen M, et al., Alternative Gnas gene products have opposite effects on glucose and lipid metabolism. Proc Natl Acad Sci U S A. 2005 May 17;102(20):7386-91
All:	62 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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