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Ihhtm1Blan
Targeted Allele Detail
Summary
Symbol: Ihhtm1Blan
Name: Indian hedgehog; targeted mutation 1, Beate Lanske
MGI ID: MGI:3609381
Synonyms: Ihhfl
Gene: Ihh  Location: Chr1:74984474-74990831 bp, - strand  Genetic Position: Chr1, 38.55 cM
Alliance: Ihhtm1Blan page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:102870
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 1, followed by a frt-flanked neomycin resistance (neo) cassette, and a second loxP site downstream of exon 1. Flp-mediated recombination removed the neo cassette. (J:102870)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 10 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ihh Mutation:  22 strains or lines available
References
Original:  J:102870 Razzaque MS, et al., Conditional deletion of Indian hedgehog from collagen type 2alpha1-expressing cells results in abnormal endochondral bone formation. J Pathol. 2005 Dec;207(4):453-61
All:  25 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory