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Slc5a3tm1Skc
Targeted Allele Detail
Summary
Symbol: Slc5a3tm1Skc
Name: solute carrier family 5 (inositol transporters), member 3; targeted mutation 1, Sookja K Chung
MGI ID: MGI:3609547
Synonyms: SMIT-
Gene: Slc5a3  Location: Chr16:91855210-91884361 bp, + strand  Genetic Position: Chr16, 53.44 cM
Alliance: Slc5a3tm1Skc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:102665
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A targeting vector was designed to replace 680 bp near the 5' end of the coding region with a PGK-neo, removing amino acids 176 to 404 in the encoded protein. Transcript was absent in kidney and brains of mutant mice. (J:102665)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc5a3 Mutation:  24 strains or lines available
References
Original:  J:102665 Chau JF, et al., Sodium/myo-inositol cotransporter-1 is essential for the development and function of the peripheral nerves. FASEB J. 2005 Nov;19(13):1887-9
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory