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Slc8a1tm2Kdp
Targeted Allele Detail
Summary
Symbol: Slc8a1tm2Kdp
Name: solute carrier family 8 (sodium/calcium exchanger), member 1; targeted mutation 2, Kenneth D Philipson
MGI ID: MGI:3609617
Synonyms: NCX-
Gene: Slc8a1  Location: Chr17:81680534-82045806 bp, - strand  Genetic Position: Chr17, 51.29 cM
Alliance: Slc8a1tm2Kdp page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:103484
Parent Cell Line:  LW1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation details: Exon 2, containing 64% of the coding sequence including the transcriptional start site, was deleted via cre mediated recombination. Immunoblot failed to detect protein in mutant embryo hearts. (J:103484)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 38 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc8a1 Mutation:  55 strains or lines available
References
Original:  J:103484 Reuter H, et al., The Na+-Ca2+ exchanger is essential for the action of cardiac glycosides. Circ Res. 2002 Feb 22;90(3):305-8
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory