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Nt5etm1Jsc
Targeted Allele Detail
Summary
Symbol: Nt5etm1Jsc
Name: 5' nucleotidase, ecto; targeted mutation 1, Jurgen Schrader
MGI ID: MGI:3609975
Synonyms: Cd73-
Gene: Nt5e  Location: Chr9:88209662-88254142 bp, + strand  Genetic Position: Chr9, 47.24 cM, cytoband E3.2
Alliance: Nt5etm1Jsc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:102299
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation details: The floxed exon 2 and neomycin resistance gene were deleted from the Nt5etm2Jsc allele via cre-mediated excision. RT-PCR detected a shortened transcript at levels similar to wild-type. The mutation caused a frame shift at the new exon 1 to 3 junction, resulting in the termination of translation after the first exon. Protein was not detected in Western blot. (J:102299)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nt5e Mutation:  30 strains or lines available
References
Original:  J:102299 Koszalka P, et al., Targeted disruption of cd73/ecto-5'-nucleotidase alters thromboregulation and augments vascular inflammatory response. Circ Res. 2004 Oct 15;95(8):814-21
All:  18 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory