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Ksr2 Gene Detail
Summary
  • Symbol
    Ksr2
  • Name
    kinase suppressor of ras 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3610315
    NCBI Gene: 333050
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:117552067-117906061 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 56.88 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    10422 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3610315
 protein coding gene Chr5:117552036-117913068 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029989
 protein coding gene Chr5:120503015-120887419 (+)
A/J MGP_AJ_G0029953
 protein coding gene Chr5:115596824-115962897 (+)
AKR/J MGP_AKRJ_G0029892
 protein coding gene Chr5:119333655-119709123 (+)
BALB/cJ MGP_BALBcJ_G0029964
 protein coding gene Chr5:117016432-117385437 (+)
C3H/HeJ MGP_C3HHeJ_G0029684
 protein coding gene Chr5:119853287-120224851 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030419
 protein coding gene Chr5:125086207-125475981 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027645
 protein coding gene Chr5:110358638-110733780 (+)
CAST/EiJ MGP_CASTEiJ_G0029093
 protein coding gene Chr5:118859469-119249984 (+)
CBA/J MGP_CBAJ_G0029652
 protein coding gene Chr5:129909814-130306641 (+)
DBA/2J MGP_DBA2J_G0029802
 protein coding gene Chr5:115696650-116061096 (+)
FVB/NJ MGP_FVBNJ_G0029758
 protein coding gene Chr5:114561549-114944590 (+)
LP/J MGP_LPJ_G0029890
 protein coding gene Chr5:121000292-121376508 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029789
 protein coding gene Chr5:134128459-134520484 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030460
 protein coding gene Chr5:118861135-119246869 (+)
PWK/PhJ MGP_PWKPhJ_G0028806
 protein coding gene Chr5:114392116-114766375 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028644
 protein coding gene Chr5:116429345-116822660 (+)
WSB/EiJ MGP_WSBEiJ_G0029168
 protein coding gene Chr5:119434887-119820148 (+)



Homology
more
  • Human Ortholog
    KSR2, kinase suppressor of ras 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KSR2, kinase suppressor of ras 2
  • Links
    NCBI Gene ID: 283455
    neXtProt AC: NX_Q6VAB6
    UniProt: Q6VAB6

  • Chr Location
    12q24.22-q24.23; chr12:117453012-117968990 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 3 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice exhibit increased body fat and obesity, resulting from hyperphagia. Mice are also glucose intolerant and have high serum cholesterol, ALT, serum lipids and show hepatic steatosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    40
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    4
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 333050 NCBI Gene Model | MGI Sequence Detail 353995 C57BL/6J ±  kb
    transcript NM_001312914 RefSeq | MGI Sequence Detail 6124 C57BL/6  
    polypeptide Q3UVC0 UniProt | EBI | MGI Sequence Detail 951 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000009592 kinase suppressor of Ras 2
      (term hierarchy)
    • EC
      2.7.11.1
    • InterPro Domains
      IPR046349 C1-like domain superfamily
      IPR025561 Kinase suppressor of RAS, SAM-like domain
      IPR046861 Kinase suppressor RAS 1, N-terminal helical hairpin
      IPR046933 Kinase suppressor RAS 1, N-terminal helical hairpin superfamily
      IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR050167 Serine/threonine-protein kinase
      IPR008271 Serine/threonine-protein kinase, active site
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR013761 Sterile alpha motif/pointed domain superfamily
    • GlyGen
      Q3UVC0 4 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 4
      cDNA 4

      Microarray probesets 1
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 20
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345122 Gomez GA, et al., Contrasting effects of Ksr2, an obesity gene, on trabecular bone volume and bone marrow adiposity. Elife. 2022 Nov 7;11:e82810
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory