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Smarca4enu1
Chemically induced Allele Detail
Summary
Symbol: Smarca4enu1
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; enu1
MGI ID: MGI:3611933
Synonyms: Brg1enu1, Smarca4m1Mag
Gene: Smarca4  Location: Chr9:21527465-21615526 bp, + strand  Genetic Position: Chr9, 7.84 cM
Alliance: Smarca4enu1 page
Mutation
origin
Strain of Origin:  C57BL/10
Mutation
description
Allele Type:    Chemically induced (ENU) (Hypomorph)
Mutation:    Single point mutation
 
Mutation details: Males carrying the curly whisker allele were mutagenized with ENU to result in this hypomorphic allele. An A to G transition in exon 23 caused an E1083G substitution in a highly conserved region of the catalytic ATPase domain. The mutation did not affect mRNA or protein stability based on Orthern blot and Wesetern blot analyses, respectively. (J:103896)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 16 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Smarca4 Mutation:  110 strains or lines available
References
Original:  J:103896 Bultman SJ, et al., A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development. Genes Dev. 2005 Dec 1;19(23):2849-61
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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11/19/2024
MGI 6.24 		The Jackson Laboratory