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Ntrk2tm1Lfp
Targeted Allele Detail
Summary
Symbol: Ntrk2tm1Lfp
Name: neurotrophic tyrosine kinase, receptor, type 2; targeted mutation 1, Luis F Parada
MGI ID: MGI:3612277
Synonyms: trkB-
Gene: Ntrk2  Location: Chr13:58954383-59281784 bp, + strand  Genetic Position: Chr13, 31.2 cM
Alliance: Ntrk2tm1Lfp page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:104489
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation details: The region encompassing the two transcription start sites and the first coding exon was deleted via homologous recombination. RT-PCR and in situ hybridization confirmed complete ablation of the locus. Neither truncated nor full-length transcript was detected. This allele was derived from Ntrk2tm2Lfp. (J:104489)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ntrk2 Mutation:  66 strains or lines available
References
Original:  J:104489 Luikart BW, et al., In vivo role of truncated trkb receptors during sensory ganglion neurogenesis. Neuroscience. 2003;117(4):847-58
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory