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Atg5tm1Nmz
Targeted Allele Detail
Summary
Symbol: Atg5tm1Nmz
Name: autophagy related 5; targeted mutation 1, Noboru Mizushima
MGI ID: MGI:3612279
Synonyms: Atg5-, Atg5KO
Gene: Atg5  Location: Chr10:44144354-44240287 bp, + strand  Genetic Position: Chr10, 23.24 cM
Alliance: Atg5tm1Nmz page
absence of otoconia (right) or the presence of giant and abnormally shaped otoconial crystals (middle) in the utricle of Atg4bGt(A029E06)Wrst/Atg4bGt(A029E06)Wrst mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70539
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neomycin resistance gene replaced exons 2 and 3, including the transcription start site. Protein was not detected in mutant ES cells by immunoblot analysis. (J:104491)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 3 assay results
In Structures Affected by this Mutation: 8 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Atg5tm1Nmz
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Atg5 Mutation:  29 strains or lines available
References
Original:  J:70539 Mizushima N, et al., Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J Cell Biol. 2001 Feb 19;152(4):657-68
All:  96 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory