Pkd1<tm2Ggg> Targeted Allele Detail MGI Mouse (MGI:3612341)

Pkd1^tm2Ggg
Targeted Allele Detail

Summary

Symbol:	Pkd1^tm2Ggg
Name:	polycystin 1, transient receptor potential channel interacting; targeted mutation 2, Gregory G Germino
MGI ID:	MGI:3612341
Synonyms:	Pkd1^cond, Pkd1^flox
Gene:	Pkd1 Location: Chr17:24768808-24815482 bp, + strand Genetic Position: Chr17, 12.4 cM
Alliance:	Pkd1^tm2Ggg page

Pkd1^tm2Ggg/Pkd1^tm2Ggg Tg(Col1a1-cre)1Bek/0 mice develop polycystic pancreas and kidney

Show the 6 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:103719
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: A neomycin cassette flanked by FRT sites and a single loxP site at the 3' end was inserted into intron 1. Another loxP site was inserted into intron 4 in the same orientation such that exons 2-4 could be removed upon expression of cre recombinase. (J:103719)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	18 assay results
In Structures Affected by this Mutation:	14 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Pkd1 Mutation:	154 strains or lines available

References

Original:	J:103719 Piontek KB, et al., A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo. J Am Soc Nephrol. 2004 Dec;15(12):3035-43
All:	70 reference(s)

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