Pcolcetm1Dgr
Targeted Allele Detail
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| Symbol: |
Pcolcetm1Dgr |
| Name: |
procollagen C-endopeptidase enhancer protein; targeted mutation 1, Daniel S Greenspan |
| MGI ID: |
MGI:3612407 |
| Synonyms: |
Pcolce- |
| Gene: |
Pcolce Location: Chr5:137603369-137609666 bp, - strand Genetic Position: Chr5, 76.59 cM
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| Alliance: |
Pcolcetm1Dgr page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:104148
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
129X1/SvJ
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin resistance cassette replaced about 2.5 kb of sequence including the entire second and third exons which encode the N-terminal portion of the CUB domain. This deletion creates a frameshift such that a truncated transcript containing nothing downstream of the signal peptide in the original frame, and only 21 amino acids downstream of the frameshift translated into the new frame. RT-PCR failed to detect wild-type transcript in mutants. Protein was not detected in mutant MEFs.
(J:104148)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Pcolce Mutation: |
70 strains or lines available
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| Original: |
J:104148 Steiglitz BM, et al., Procollagen C proteinase enhancer 1 genes are important determinants of the mechanical properties and geometry of bone and the ultrastructure of connective tissues. Mol Cell Biol. 2006 Jan;26(1):238-49 |
| All: |
2 reference(s) |
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Analysis Tools
