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Tg(Gnrh1-cre)1Rsp
Transgene Detail
Summary
Symbol: Tg(Gnrh1-cre)1Rsp
Name: transgene insertion 1, Rolf Sprengel
MGI ID: MGI:3612443
Synonyms: TgGnRH-iCre
Transgene: Tg(Gnrh1-cre)1Rsp  Location: unknown  
Alliance: Tg(Gnrh1-cre)1Rsp page
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(Gnrh1-cre)1Rsp expression driven by 1 gene
 
Mutation details: The mouse gonadotropin-releasing hormone promoter was used to drive the expression of improved cre (icre). The icre was assembled from oligonucleotides to introduce silent base mutations corresponding to human codon-usage preferences, minimize CpG content, eliminate putative cryptic splice sites and alter the stop codon. Cre activity was detected in 97% of Gnrh immunopositive neurons and in a second population of cells, mainly the limbic system neurons. Four lines exhibiting high expression and three with low expression were obtained. This is a representative from those lines. (J:78663)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Gnrh1 (mouse)
Summary of all recombinase alleles driven by Gnrh1.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:78663 Shimshek DR, et al., Codon-improved Cre recombinase (iCre) expression in the mouse. Genesis. 2002 Jan;32(1):19-26
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory