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Gdf3tm1Mms
Targeted Allele Detail
Summary
Symbol: Gdf3tm1Mms
Name: growth differentiation factor 3; targeted mutation 1, Michael M Shen
MGI ID: MGI:3612535
Synonyms: Bf-Gdf3
Gene: Gdf3  Location: Chr6:122582362-122587046 bp, - strand  Genetic Position: Chr6, 57.7 cM
Alliance: Gdf3tm1Mms page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:104371
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted
Mutation:    Insertion
 
Mutation details: The prodomain was replaced with that of Xenopus Bmp2 with a FLAG or V5 epitope tag at the N-terminus of the mature ligand. The resulting fusion protein was expressed. Several proteins were detected by Western blot. (J:104371)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gdf3 Mutation:  40 strains or lines available
References
Original:  J:104371 Chen C, et al., The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo. Development. 2006 Jan;133(2):319-29
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory