Summary | Transgene origin | Transgene description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Sclt1Tg(CAG-sb10)1Dla
Name:	sodium channel and clathrin linker 1; transgene insertion 1, David A Largaespada
MGI ID:	MGI:3612989
Synonyms:	CAGGS-SB10, Tg(ACTB-sb10)1Dla, Tg(CAG-sb10)1Dla
Gene:	Sclt1  Location: Chr3:41581155-41696949 bp, - strand  Genetic Position: Chr3, 19.91 cM, cytoband C
Alliance:	Sclt1Tg(CAG-sb10)1Dla page

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Null/knockout, Transposase) Mutations:    Insertion, Intragenic deletion   Mutation details: The ubiquitously expressed CAGGS chimeric promoter derived from chicken beta-actin and CMV immediate early promoter sequences drives expression of the sleeping beauty 10 (sb10) transposase. The transgene caused a 3 kb deletion in and inserted into intron 12 of the host gene. RNA-seq confirmed the absence of transcription from exons 13 onward. (J:70414)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

List all tumor models in MMHCdb carrying Sclt1Tg(CAG-sb10)1Dla

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sclt1 Mutation:	39 strains or lines available

Original:	J:70414 Dupuy AJ, et al., Transposition and gene disruption in the male germline of the mouse. Genesis. 2001 Jun;30(2):82-8
All:	11 reference(s)