Summary | Transgene origin | Transgene description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Sclt1Tg(CAG-sb10)1Dla
Name:	sodium channel and clathrin linker 1; transgene insertion 1, David A Largaespada
MGI ID:	MGI:3612989
Synonyms:	CAGGS-SB10, Tg(ACTB-sb10)1Dla, Tg(CAG-sb10)1Dla
Gene:	Sclt1  Location: Chr3:41581155-41696949 bp, - strand  Genetic Position: Chr3, 19.91 cM, cytoband C
Alliance:	Sclt1Tg(CAG-sb10)1Dla page

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Null/knockout, Transposase) Mutations:    Insertion, Intragenic deletion   Mutation details: The ubiquitously expressed CAGGS chimeric promoter derived from chicken beta-actin and CMV immediate early promoter sequences drives expression of the sleeping beauty 10 (sb10) transposase. The transgene caused a 3 kb deletion in and inserted into intron 12 of the host gene. RNA-seq confirmed the absence of transcription from exons 13 onward. (J:70414)

Key:	hm homozygous ht heterozygous tg involves transgenes √ phenotype observed cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/ Background:	Allelic Composition Genetic Background Cell Line(s) Allelic Composition Genetic Background Cell Line(s) Loading... hm1  Disease Model Sclt1Tg(CAG-sb10)1Dla/Sclt1Tg(CAG-sb10)1Dla FVB/N-Sclt1Tg(CAG-sb10)1Dla   cx2 Sclt1Tg(CAG-sb10)1Dla/0 TgTn(sb-T2/Onc)68Dla/0 FVB/N-TgTn(sb-T2/Onc)68Dla Sclt1Tg(CAG-sb10)1Dla   cx3 Sclt1Tg(CAG-sb10)1Dla/0 TgTn(sb-T2/Onc)76Dla/0 FVB/N-TgTn(sb-T2/Onc)76Dla Sclt1Tg(CAG-sb10)1Dla   cx4 Cdkn2atm1Cjs/Cdkn2atm1Cjs Sclt1Tg(CAG-sb10)1Dla/0 TgTn(sb-T2/Onc)76Dla/0 involves: 129X1/SvJ * FVB/N   cx5 Cdkn2atm1Cjs/Cdkn2atm1Cjs Sclt1Tg(CAG-sb10)1Dla/0 TgTn(sb-T2/Onc)68Dla/0 involves: 129X1/SvJ * FVB/N
Phenotypes:	Affected Systems hm1 cx2 cx3 cx4 cx5 show or hide all annotated terms           craniofacial √ cleft palate √ digestive/alimentary system √ cleft palate √ decreased intestine length √ growth/size/body √ growth/size/body region phenotype N cleft palate √ slow postnatal weight gain √ cachexia √ kidney medulla cyst √ polycystic kidney √ enlarged kidney √ homeostasis/metabolism √ increased blood urea nitrogen level √ limbs/digits/tail √ preaxial polydactyly √ mortality/aging √ √ √ premature death √ √ √ neoplasm N N √ √ neoplasm N N increased tumor incidence √ √ increased leukemia incidence √ √ increased lymphoma incidence √ √ increased lung adenocarcinoma incidence √ √ increased sarcoma incidence √ √ increased osteosarcoma incidence √ √ renal/urinary system √ abnormal kidney morphology √ kidney medulla cyst √ polycystic kidney √ enlarged kidney √ renal fibrosis √ respiratory system √ √ increased lung adenocarcinoma incidence √ √ skeleton √ √ increased osteosarcoma incidence √ √

View phenotypes and curated references for all genotypes (concatenated display).

Key:	√ disease model   expected model not found
Models:	Human Diseases hm1 autosomal recessive polycystic kidney disease IDs autosomal recessive polycystic kidney disease       DOID:0110861 ICD10CM:Q61.1 ICD9CM:753.14 MESH:D017044 NCI:C84579 ORDO:731 UMLS_CUI:C0085548 Close √ ciliopathy IDs ciliopathy       DOID:0060340 Close √

In Structures Affected by this Mutation:

4 anatomical structure(s)

List all tumor models in MMHCdb carrying Sclt1Tg(CAG-sb10)1Dla

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sclt1 Mutation:	39 strains or lines available

Original:	J:70414 Dupuy AJ, et al., Transposition and gene disruption in the male germline of the mouse. Genesis. 2001 Jun;30(2):82-8
All:	11 reference(s)