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Dnmt1tm4Jae
Targeted Allele Detail
Summary
Symbol: Dnmt1tm4Jae
Name: DNA methyltransferase 1; targeted mutation 4, Rudolf Jaenisch
MGI ID: MGI:3613486
Synonyms: 2frt
Gene: Dnmt1  Location: Chr9:20818501-20871084 bp, - strand  Genetic Position: Chr9, 7.66 cM
Alliance: Dnmt1tm4Jae page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:104860
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: A stop cassette flanked by two Frt sites was inserted between the fourth and fifth exons. Upon Flp expression, the allele resumes function as the stop cassette is removed. (J:104860)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dnmt1 Mutation:  112 strains or lines available
Notes
Mouse embryo fibroblasts derived from chimeric mice made with Dnmt1tm2Jae/Dnmt1tm4Jae ES cells in which imprinting had been eliminated (J:104860) display a significantly faster growth rate with nearly half (47%) of cells in the G2 or M phase of the cell cycle. These MEF cells become spontaneously immortalized. The chimeric mice experience widespread tumorigenesis.
References
Original:  J:104860 Holm TM, et al., Global loss of imprinting leads to widespread tumorigenesis in adult mice. Cancer Cell. 2005 Oct;8(4):275-85
All:  5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory