Tg(YAC128)53Hay Transgene Detail MGI Mouse (MGI:3613515)

Tg(YAC128)53Hay
Transgene Detail

Summary

Symbol:	Tg(YAC128)53Hay
Name:	transgene insertion 53, Michael Hayden
MGI ID:	MGI:3613515
Synonyms:	HD53, YAC 128, YAC128
Transgene:	Tg(YAC128)53Hay Location: unknown
Alliance:	Tg(YAC128)53Hay page

Transgene
origin

Strain of Origin:

FVB/N

Transgene
description

Transgene Type:

Transgenic (Humanized sequence, Inserted expressed sequence)

Mutation:

Insertion

Tg(YAC128)53Hay expresses 1 gene

Mutation details: A YAC containing a full-length human huntingtin gene under the control of the endogenous human HDH promoter was modified with a 128 CAG repeat expansion. The resulting construct (YAC128) was used to generate transgenic mice. Founder line 53 integrated the most copies of the transgene and had the highest levels of protein expression (75% of endogenous levels) as determined by densitometric analysis. (J:84453)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available Cell Lines: 0 lines available

References

Original:	J:84453 Slow EJ, et al., Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease. Hum Mol Genet. 2003 Jul 1;12(13):1555-67
All:	54 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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