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F10tm1Edr
Targeted Allele Detail
Summary
Symbol: F10tm1Edr
Name: coagulation factor X; targeted mutation 1, Elliot D Rosen
MGI ID: MGI:3613747
Synonyms: FX-
Gene: F10  Location: Chr8:13087308-13106676 bp, + strand  Genetic Position: Chr8, 5.73 cM
Alliance: F10tm1Edr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:61230
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neomycin resistance cassette replaced 18kb of sequence including exons 2-8, which encode the mature protein. RT-PCR analysis did not detect transcript in liver from homozygous E17.5 mutant embryos. Immunohistochemical analysis did not detect protein in liver sections from homozygous E17.5 mutant embryos. (J:61230)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any F10 Mutation:  29 strains or lines available
References
Original:  J:61230 Dewerchin M, et al., Blood coagulation factor X deficiency causes partial embryonic lethality and fatal neonatal bleeding in mice. Thromb Haemost. 2000 Feb;83(2):185-90
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory