Hoxd<tm21(Hoxd11)Ddu> Targeted Allele Detail MGI Mouse (MGI:3616018)

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Hoxd^{tm21(Hoxd11)Ddu}
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Hoxd^{tm21(Hoxd11)Ddu}
Name:	homeobox D cluster; targeted mutation 21, Denis Duboule
MGI ID:	MGI:3616018
Synonyms:	del(1-13), Del1Ddu, Del(2Hoxd1-Hoxd13)1Ddu, TgH(d11/lac/Del9)Ge
Gene:	Hoxd Location: unknown Genetic Position: Chr2, Syntenic

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:70547
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Intergenic deletion, Intragenic deletion
		Hoxd^{tm21(Hoxd11)Ddu} involves 16 genes/genome features (Hoxd13, Hoxd12, Hoxd11 ...) View all
		Mutation details: This allele was created in the same ES cells used to create Hoxd^{tm18.1(Hoxd11)Ddu} and thus has a Hoxd11/lacZ/loxP site located 5' of Hoxd13. A lacZ reporter sequence followed by a PGKneo selection cassette was inserted into exon 2 of Hoxd1. In vitro cre expression removed the entire Hoxd cluster replacing it with a Hoxd11/lacZ fusion gene. (J:70547)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	121 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Hoxd Mutation:	0 strains or lines available

References

Original:	J:70547 Zakany J, et al., Localized and transient transcription of Hox genes suggests a link between patterning and the segmentation clock. Cell. 2001 Jul 27;106(2):207-17
All:	17 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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