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Hoxdtm21(Hoxd11)Ddu
Targeted Allele Detail
Summary
Symbol: Hoxdtm21(Hoxd11)Ddu
Name: homeobox D cluster; targeted mutation 21, Denis Duboule
MGI ID: MGI:3616018
Synonyms: del(1-13), Del1Ddu, Del(2Hoxd1-Hoxd13)1Ddu, TgH(d11/lac/Del9)Ge
Gene: Hoxd  Location: unknown  Genetic Position: Chr2, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70547
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Intergenic deletion, Intragenic deletion
  Hoxdtm21(Hoxd11)Ddu involves 16 genes/genome features (Hoxd13, Hoxd12, Hoxd11 ...) View all
 
Mutation details: This allele was created in the same ES cells used to create Hoxdtm18.1(Hoxd11)Ddu and thus has a Hoxd11/lacZ/loxP site located 5' of Hoxd13. A lacZ reporter sequence followed by a PGKneo selection cassette was inserted into exon 2 of Hoxd1. In vitro cre expression removed the entire Hoxd cluster replacing it with a Hoxd11/lacZ fusion gene. (J:70547)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 121 assay results
2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxd Mutation:  0 strains or lines available
References
Original:  J:70547 Zakany J, et al., Localized and transient transcription of Hox genes suggests a link between patterning and the segmentation clock. Cell. 2001 Jul 27;106(2):207-17
All:  17 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory