Vezttm1Smc
Targeted Allele Detail
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| Symbol: |
Vezttm1Smc |
| Name: |
vezatin, adherens junctions transmembrane protein; targeted mutation 1, Marie C Simmler |
| MGI ID: |
MGI:3618233 |
| Synonyms: |
Vezatinflox, Veztfl |
| Gene: |
Vezt Location: Chr10:93797384-93871661 bp, - strand Genetic Position: Chr10, 48.72 cM
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| Alliance: |
Vezttm1Smc page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:121686
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| Parent Cell Line: |
CK35 (ES Cell)
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| Strain of Origin: |
129S2/SvPas
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| Allele Type: |
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Targeted (Conditional ready, No functional change) |
| Mutation: |
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Insertion
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Mutation details: A loxP site resides immediately upstream of exon 5, which is followed by a loxP-flanked Pgk1-neo cassette. Crossing mice homozygous for this allele to mice expressing Cre recombinase under control of a selected promoter results in developmental-stage or tissue-specific deletion of exon 5, which encodes the transmembrane domain shared by all three predicted isoforms of the protein. Reverse transcription- (RT-) PCR demonstrated expression of the expected 8-kb transcript in ES cells and in 8-cell- and blastocyst-stage embryos homozygous for this mutation.
(J:121686)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Original: |
J:121686 Hyenne V, et al., Conditional knock-out reveals that zygotic vezatin-null mouse embryos die at implantation. Mech Dev. 2007 Jul;124(6):449-62 |
| All: |
3 reference(s) |
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Analysis Tools
