Tbx1<tm2.1Bem> Targeted Allele Detail MGI Mouse (MGI:3619149)

Tbx1^tm2.1Bem
Targeted Allele Detail

Summary

Symbol:	Tbx1^tm2.1Bem
Name:	T-box 1; targeted mutation 2.1, Bernice E Morrow
MGI ID:	MGI:3619149
Synonyms:	Tbx1^flox, Tbx1^tm1.1Bem
Gene:	Tbx1 Location: Chr16:18399729-18409412 bp, - strand Genetic Position: Chr16, Syntenic
Alliance:	Tbx1^tm2.1Bem page

Fourth pharyngeal arch artery aplasia in Tbx1^tm2.1Bem/Tbx1⁺ Tfap2a^tm1(cre)Moon/Tfap2a⁺ mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:105980
Parent Cell Line:	WW6 (ES Cell)
Strain of Origin:	STOCK 129/Sv and C57BL/6J and SJL

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Exons 2 and 3 were flanked with loxP sites. The ATG is in exon 2. (J:105980)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	59 assay results 7 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	31 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Tbx1 Mutation:	36 strains or lines available

References

Original:	J:105980 Arnold JS, et al., Inactivation of Tbx1 in the pharyngeal endoderm results in 22q11DS malformations. Development. 2006 Mar;133(5):977-87
All:	15 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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