About   Help   FAQ
Braftm1Sva
Targeted Allele Detail
Summary
Symbol: Braftm1Sva
Name: Braf transforming gene; targeted mutation 1, Alcino J Silva
MGI ID: MGI:3620008
Synonyms: B-raff
Gene: Braf  Location: Chr6:39580171-39702397 bp, - strand  Genetic Position: Chr6, 18.43 cM
Alliance: Braftm1Sva page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:107042
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: A targeting construct was designed to flank exon 12 (exon 9 according to nomenclature in J:29234) with loxP sites. This exon is the first to encode the kinase domain. Its excision would result in a frame shift in the ORF, resulting in a null mutation. Western blot confirmed that insertion of the loxP sites did not affect protein expression levels. (J:107042)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Braf Mutation:  60 strains or lines available
References
Original:  J:107042 Chen AP, et al., Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory. J Neurosci Res. 2006 Jan;83(1):28-38
All:  22 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory