Ofd1<tm1Bfra> Targeted Allele Detail MGI Mouse (MGI:3620081)

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Ofd1^tm1Bfra
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Ofd1^tm1Bfra
Name:	OFD1, centriole and centriolar satellite protein; targeted mutation 1, Brunella Franco
MGI ID:	MGI:3620081
Synonyms:	Ofd1delta4-5
Gene:	Ofd1 Location: ChrX:165173029-165223700 bp, - strand Genetic Position: ChrX, 77.28 cM
Alliance:	Ofd1^tm1Bfra page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:106035
Parent Cell Line:	TBV2 (ES Cell)
Strain of Origin:	129S2/SvPas

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Intragenic deletion
		Mutation details: Exons 4 and 5 were flanked by loxP sites via homologous recombination. The Frt flanked neo cassette was removed by Flp recombinase in the ES cells. After Cre mediated recombination RT-PCR confirmed absence of these exons from transcripts in mutants and Western blot analysis failed to detect protein from recombined embryos. This allele was generated from Ofd1^tm2.1Bfra (J:106035)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Ofd1 Mutation:	14 strains or lines available

References

Original:	J:106035 Ferrante MI, et al., Oral-facial-digital type I protein is required for primary cilia formation and left-right axis specification. Nat Genet. 2006 Jan;38(1):112-7
All:	4 reference(s)

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