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Plod3tm2.1Rmyl
Targeted Allele Detail
Summary
Symbol: Plod3tm2.1Rmyl
Name: procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3; targeted mutation 2.1, Raili Myllyla
MGI ID: MGI:3620603
Synonyms: LH
Gene: Plod3  Location: Chr5:137015873-137025500 bp, + strand  Genetic Position: Chr5, 76.09 cM
Alliance: Plod3tm2.1Rmyl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:106510
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Hypomorph, Inserted expressed sequence)
Mutation:    Insertion
 
Mutation details: An Asp669Ala mutation was introduced into exon 18 in order to disrupt the lysyl hydroxylase activity. (J:106510)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Plod3 Mutation:  60 strains or lines available
References
Original:  J:106510 Ruotsalainen H, et al., Glycosylation catalyzed by lysyl hydroxylase 3 is essential for basement membranes. J Cell Sci. 2006 Feb 15;119(Pt 4):625-35
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory