Tg(KRT5-Erbb2)1Jdg Transgene Detail MGI Mouse (MGI:3510988)

Tg(KRT5-Erbb2)1Jdg
Transgene Detail

Summary

Symbol:	Tg(KRT5-Erbb2)1Jdg
Name:	transgene insertion 1, John DiGiovanni
MGI ID:	MGI:3510988
Synonyms:	BK5.erbB2A, BK5.ErbB-2A
Transgene:	Tg(KRT5-Erbb2)1Jdg Location: unknown
Alliance:	Tg(KRT5-Erbb2)1Jdg page

Transgene
origin

Strain of Origin:

FVB

Transgene
description

Transgene Type:

Transgenic (Inserted expressed sequence)

Mutation:

Insertion

Tg(KRT5-Erbb2)1Jdg expresses 1 gene

Tg(KRT5-Erbb2)1Jdg expression driven by 1 gene

Mutation details: A rat Erbb2 cDNA under regulatory control of the bovine keratin 5 promoter was used for the transgene. A rabbit beta-globin intron and SV40 polyadenylation sequence was also included in the construct. Transgene expression in basal epidermal cells was confirmed by immunofluorescence of dorsal skin and skin tumor sections. (J:64524)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Three transgenic founder lines were established. Transgenic line BK5.erbB2A displayed the highest level of transgene expression and was used for all experiments. By 6 months of age, 10% of hemizygous BK5.erbB2A animals and 90% of homozygous BK5.erbB2A animals developed spontaneous papillomas.

References

Original:	J:64524 Kiguchi K, et al., Constitutive expression of erbB2 in epidermis of transgenic mice results in epidermal hyperproliferation and spontaneous skin tumor development. Oncogene. 2000 Aug 31;19(37):4243-54
All:	5 reference(s)

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