Tg(Lck-ADPRT)1Tmo
Transgene Detail
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| Symbol: |
Tg(Lck-ADPRT)1Tmo |
| Name: |
transgene insertion 1, Tarik Moroy |
| MGI ID: |
MGI:2446675 |
| Synonyms: |
lck-PARP DBD #1 |
| Transgene: |
Tg(Lck-ADPRT)1Tmo Location: unknown
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| Alliance: |
Tg(Lck-ADPRT)1Tmo page
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| Transgene Type: |
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Transgenic (Dominant negative, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Mutation details: The Lck promoter was observed to drive expression in the T-cell containing tissues including the thymus, spleen and lymph nodes. The highest levels of expression were observed in thymic tissue. Immunohistochemical analysis of T-cell containing tissues confirmed overexpression of a dominant negative peptide consisting of the DNA binding domain (residues 1 through 376) of the human ADP-ribosyltransferase protein. Analysis of thymocytes obtained from mice originating from founder line 2, showed ADP-ribose polymer formation to be inhibitied.
(J:80883)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:80883 Beneke R, et al., DNA excision repair and DNA damage-induced apoptosis are linked to Poly(ADP-ribosyl)ation but have different requirements for p53. Mol Cell Biol. 2000 Sep;20(18):6695-703 |
| All: |
2 reference(s) |
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Analysis Tools
