Hprt1<tm1(Pck1-cre)Vhh> Targeted Allele Detail MGI Mouse (MGI:3621174)

Hprt1^{tm1(Pck1-cre)Vhh}
Targeted Allele Detail

Summary

Symbol:	Hprt1^{tm1(Pck1-cre)Vhh}
Name:	hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Volker H Haase
MGI ID:	MGI:3621174
Synonyms:	PEPCK-Cre
Gene:	Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
Alliance:	Hprt1^{tm1(Pck1-cre)Vhh} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:106705
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:

Targeted (Recombinase)

Mutation:

Insertion

Hprt1^{tm1(Pck1-cre)Vhh} expression driven by 1 gene

Mutation details: The rat phosphoenolpyruvate carboxykinase 1, cytosolic promoter was used to drive expression of cre recombinase in the renal proximal tubule. The promoter was mutated in such a way that expression in the liver was reduced by 60% and increased in the kidney by 10-fold in mutant mice. The construct was inserted into ES cells lacking Hprt. (J:106705)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pck1 (rat) Summary of all recombinase alleles driven by Pck1. Alliance rat Pck1 gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Hprt1 Mutation:	1279 strains or lines available

References

Original:	J:106705 Rankin EB, et al., Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor. Cancer Res. 2006 Mar 1;66(5):2576-83
All:	63 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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