Tg(Tcra2C,Tcrb2C)1Dlo
Transgene Detail
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| Symbol: |
Tg(Tcra2C,Tcrb2C)1Dlo |
| Name: |
transgene insertion 1, Dennis Y Loh |
| MGI ID: |
MGI:3621454 |
| Synonyms: |
2C TCR, 2C TCR-Tg |
| Transgene: |
Tg(Tcra2C,Tcrb2C)1Dlo Location: unknown
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| Alliance: |
Tg(Tcra2C,Tcrb2C)1Dlo page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Tcra2C,Tcrb2C)1Dlo expresses
2 genes
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Mutation details: The transgene constructs encode a T cell receptor (TCR) that recognizes the Ld class I major histocompatibility complex (MHC) antigen SIYRYYGL peptide in the context of the H2b MHC class I molecule. Rearranged genomic cosmids containing the entire Tcra and Tcrb coding and promoter regions from the cytotoxic T cell clone 2C were isolated and coinjected into fertilized eggs. Transgenic H2b mice have large numbers of T cells in the periphery that express the transgenic TCR. In the periphery of transgenic H2d mice, T cells expressing the transgenic TCR are deleted.
(J:107523, J:120081)
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| Key: |
| hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/
Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
|---|
Loading... | | | involves: 129S4/SvJae * C57BL/6 * C57L * CBA * ICR * SJL | | | | involves: C57BL/10 * DBA/2 | | | | involves: C57BL/6 * SJL | | | | involves: C57L * DBA/2 * SJL | |
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| Phenotypes: |
| Affected Systems |
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endocrine/exocrine glands
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thymus hypoplasia
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decreased thymocyte number
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hematopoietic system
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√
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thymus hypoplasia
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√
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increased double-negative T cell number
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√
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increased CD4-positive, alpha-beta T cell number
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√
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decreased lymphocyte cell number
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√
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decreased thymocyte number
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√
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abnormal CD8-positive, alpha beta T cell morphology
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√
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abnormal memory T cell physiology
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immune system
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√
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√
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√
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thymus hypoplasia
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√
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increased double-negative T cell number
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√
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increased CD4-positive, alpha-beta T cell number
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√
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decreased lymphocyte cell number
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√
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decreased thymocyte number
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√
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abnormal CD8-positive, alpha beta T cell morphology
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√
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abnormal memory T cell physiology
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√
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seborrheic dermatitis
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√
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integument
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N
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√
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integument phenotype
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N
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seborrheic dermatitis
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√
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abnormal dermis papillary layer morphology
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√
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thick epidermis
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√
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respiratory system
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√
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emphysema
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:107523 Sha WC, et al., Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice. Nature. 1988 Sep 15;335(6187):271-4 |
| All: |
94 reference(s) |
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Analysis Tools
