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Lrp4tm1Her
Targeted Allele Detail
Summary
Symbol: Lrp4tm1Her
Name: low density lipoprotein receptor-related protein 4; targeted mutation 1, Joachim Herz
MGI ID: MGI:3621893
Synonyms: Lrp4ECD, Lrp4hypo, Megf7-
Gene: Lrp4  Location: Chr2:91287856-91344124 bp, + strand  Genetic Position: Chr2, 50.63 cM
Alliance: Lrp4tm1Her page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:106811
Parent Cell Line:  SM1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: The locus was disrupted by the insertion of a stop codon just upstream of the transmembrane segment. Part of exon 36 and 2.1 kb of intron 36 were replaced with a neomycin resistance cassette. RT-PCR confirmed the complete lack of functional transcripts. (J:106811)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 55 assay results
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lrp4 Mutation:  98 strains or lines available
References
Original:  J:106811 Johnson EB, et al., Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice. Hum Mol Genet. 2005 Nov 15;14(22):3523-38
All:  8 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory