Dner<tm1Hta> Targeted Allele Detail MGI Mouse (MGI:3621906)

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Dner^tm1Hta
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Dner^tm1Hta
Name:	delta/notch-like EGF repeat containing; targeted mutation 1, Hiroshi Takeshima
MGI ID:	MGI:3621906
Synonyms:	Dner^-
Gene:	Dner Location: Chr1:84347560-84673942 bp, - strand Genetic Position: Chr1, 43.4 cM
Alliance:	Dner^tm1Hta page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:106886
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Exon 1 was replaced with a neomycin resistance gene. Western blot failed to detect protein in mutants. (J:106886)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Dner Mutation:	52 strains or lines available

References

Original:	J:106886 Tohgo A, et al., Impaired cerebellar functions in mutant mice lacking DNER. Mol Cell Neurosci. 2006 Feb;31(2):326-33
All:	3 reference(s)

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