Reck<tm1Ito> Targeted Allele Detail MGI Mouse (MGI:3623517)

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Reck^tm1Ito
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Reck^tm1Ito
Name:	reversion-inducing-cysteine-rich protein with kazal motifs; targeted mutation 1, Shigeyoshi Itohara
MGI ID:	MGI:3623517
Synonyms:	Reck^-
Gene:	Reck Location: Chr4:43875530-43944806 bp, + strand Genetic Position: Chr4, 23.05 cM
Alliance:	Reck^tm1Ito page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:107674
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A targeting vector was designed to replace exon 1 with a PGK-neo cassette. Northern and Western blot analyses confirmed absence of transcript and protein, respectively. (J:107674)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Reck Mutation:	46 strains or lines available

References

Original:	J:107674 Oh J, et al., The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Cell. 2001 Dec 14;107(6):789-800
All:	8 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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