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H6pdtm1Pmst
Targeted Allele Detail
Summary
Symbol: H6pdtm1Pmst
Name: hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase); targeted mutation 1, Paul M Stewart
MGI ID: MGI:3624665
Gene: H6pd  Location: Chr4:150063932-150093480 bp, - strand  Genetic Position: Chr4, 80.65 cM
Alliance: H6pdtm1Pmst page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:108281
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Exons 2 and 3 were replaced by a neomycin resistance gene. Absence of protein was confirmed by immunoblot of mutant liver microsomes. (J:108281)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any H6pd Mutation:  60 strains or lines available
References
Original:  J:108281 Lavery GG, et al., Hexose-6-phosphate dehydrogenase knock-out mice lack 11 beta-hydroxysteroid dehydrogenase type 1-mediated glucocorticoid generation. J Biol Chem. 2006 Mar 10;281(10):6546-51
All:  9 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory