Prkratm1Gcs
Targeted Allele Detail
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| Symbol: |
Prkratm1Gcs |
| Name: |
protein kinase, interferon inducible double stranded RNA dependent activator; targeted mutation 1, Ganes C Sen |
| MGI ID: |
MGI:3626341 |
| Synonyms: |
Pact- |
| Gene: |
Prkra Location: Chr2:76460242-76478359 bp, - strand Genetic Position: Chr2, 45.07 cM
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| Alliance: |
Prkratm1Gcs page
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External and internal ear abnormalities in Prkratm1Gcs/Prkratm1Gcs mice
Show the 2 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:108297
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A targeting vector was designed to replace about 500 bp of sequence encoding the PKR activation domain in exon 8 with a neomycin resistance cassette. No truncated protein was expressed. The mutant hybrid mRNA was shown to contain 1-22 bases of the endogenous sequence, intron 7, 923-934 of the disrupted exon 8 and the entire neo cassette.
(J:108297)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Prkra Mutation: |
24 strains or lines available
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| Original: |
J:108297 Rowe TM, et al., A role of the double-stranded RNA-binding protein PACT in mouse ear development and hearing. Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5823-8 |
| All: |
6 reference(s) |
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Analysis Tools
