About   Help   FAQ
Kcnj8gnite
Chemically induced Allele Detail
Summary
Symbol: Kcnj8gnite
Name: potassium inwardly-rectifying channel, subfamily J, member 8; goodnight
MGI ID: MGI:3626348
Gene: Kcnj8  Location: Chr6:142510563-142517340 bp, - strand  Genetic Position: Chr6, 74.31 cM
Alliance: Kcnj8gnite page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutations:    Intragenic deletion, Inversion
  Kcnj8gnite involves 1 genes/genome features (Kcnj8) View all
 
Mutation details: Goodnight mice exhibit the same phenotype as mayday mice, which contain a mutation in Kcnj8. Although they arose in distinct pedigrees, complementation testing indicated that goodnight is allelic with mayday. Sequencing revealed that the goodnight allele contains the same mutation as the mayday allele. The mutation in Kcnj8 consists of a deletion of exon 1 and most of exon 2, due to their replacement by an inverted segment of intron 2. (J:88776, J:126658)
Inheritance:    Recessive
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnj8 Mutation:  34 strains or lines available
Notes
The mutation was identified as a result of immunocompromise observed in progeny of ENU-mutagenized mice during infection with mouse cytomegalovirus (MCMV). Mice carrying this mutation show higher susceptibility than that observed in susceptible BALB/c mice.
References
Original:  J:105543 Crozat K, et al., Analysis of the MCMV resistome by ENU mutagenesis. Mamm Genome. 2006 May;17(5):398-406
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory